A4888
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A4888
Sigma
Amphotericin B from Streptomyces sp.
~80% (HPLC), powder
| Synonym: | Fungizone |
| CAS Number: | 1397-89-3 |
| Linear Formula: | C47H73NO17 |
| Molecular Weight: | 924.08 |
| Beilstein Registry Number: | 78342 |
| EC Number: | 215-742-2 |
| MDL number: | MFCD00877763 |
| PubChem Substance ID: | 24890749 |
Description
| Biochem/physiol Actions | Polyene antifungal antibiotic from Streptomyces. Affinity for sterols, primarily ergosterols, of fungal cell membranes. Forms channels in the membranes, causing small molecules to leak out. Antimicrobial spectrum: fungi and yeast. |
Properties
| assay | ~80% (HPLC) |
| form | powder |
| solubility | DMF: 2-4 mg/mL |
| DMSO: 30-40 mg/mL | |
| H2O: insoluble | |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | BU2625000 |
References
| reference | Perlman, D., Use of antibiotics in cell culture media. Meth. Enzymol. LVIII, 112, (1979) |
| Merck | Merck 13,590 |
| Beilstein | Beil. 18,V,10,525 |
